Janssen-Cilag International NV, a Johnson & Johnson (JNJ) company, announced new data from the Phase 1b/2 OrigAMI-1 study, which showed amivantamab combined with chemotherapy (mFOLFOX6 [FOLFOX] or FOLFIRI) demonstrated promising rapid and durable antitumour activity in patients with RAS/BRAF wild-type (WT) metastatic colorectal cancer or mCRC who have not previously received anti-epidermal growth factor receptor or EGFR therapy.
The company noted that patients treated with amivantamab plus chemotherapy achieved an overall response rate (ORR) of 49 percent, median duration of response of 7.4 months and median progression-free survival of 7.5 months. Disease control was observed in 88 percent of patients. Clinically meaningful intrahepatic antitumour activity was observed among patients with liver metastases treated with amivantamab plus chemotherapy, demonstrating a significant reduction in liver tumours (ORR of 53 percent, disease control rate of 93 percent). Notably, nine (21 percent) patients were able to proceed to curative intent surgery due to strong anti-tumour activity.
Colorectal cancer is the third most common cancer worldwide and the second most common cancer in Europe, with over 538,000 people diagnosed in 2022.
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April 24, 2026 15:15 ET Economics news flow was relatively light this week even as the conflict in the Middle East continued, raising concerns for policymakers. In the U.S., spending data, initial jobless claims and pending home sales were the highlights. Business confidence in the biggest euro area economy was in focus in Europe. Inflation data from Japan gained attention in Asia.