4D Molecular Therapeutics (FDMT) announced positive initial interim 52-week data from the Phase 2b Population Extension cohort of the PRISM clinical trial evaluating 4D-150 in a broad wet age-related macular degeneration (wet AMD) patient population. Additional data were provided on the durability of aflibercept expression for up to two years.
The treatment with 3E10 vg/eye led to an impressive 83% reduction in injection burden compared to the projected on-label aflibercept 2 mg administered every eight weeks. Furthermore, 70% of patients required only 0-1 supplemental injection, and 57% remained injection-free through the 52-week period.
In the recently diagnosed subgroup, which most resembles the Phase 3 4FRONT-1 and 4FRONT-2 patient populations, 87% required 0-1 supplemental injection and 80% were injection-free through 52 weeks.
The durable and stable expression of aflibercept was demonstrated across all 3E10 vg/eye PRISM cohorts, with follow-up extending up to two years. Additionally, 4D-150 has shown continued tolerability, with follow-up periods reaching up to three years.
For More Such Health News, visit rttnews.com
For comments and feedback contact: editorial@rttnews.com
Business News
May 22, 2026 14:46 ET Minutes of the latest Fed policy session was the highlight of the week along with survey data on the U.S. housing market. In Europe, survey data signaled the trends in the euro area private sector. Further, consumer price inflation data from the U.K. was in focus. In Asia, various economic indicators from China drew attention to the health of the economy.