argenx SE (ARGX) announced that it plans to advance ARGX-119—a first-in-class agonist antibody targeting muscle-specific kinase (MuSK)—to a registrational study in patients with congenital myasthenic syndromes, following topline data from its Phase 1b trial.
Congenital Myasthenic Syndromes (CMS) are an ultra-rare and heterogenous group of congenital neuromuscular disorders caused by genetic defects that are essential for the integrity of the neuromuscular junction.
The company noted that ARGX-119 is the sixth molecule developed through our Immunology Innovation Program to show proof-of-concept, reflecting the strength of its innovation model where its deep knowledge of the biology and expertise in antibody engineering come together to push the boundaries of what's possible.
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