Quick Facts
FONT-SIZE Plus   Neg
Share SHARE

AVEO Reports Publication Of Positive Tivozanib Phase 2 Results - Quick Facts

AVEO Pharmaceuticals Inc. (AVEO: Quote) said the previously reported results from a Phase 2 trial evaluating the efficacy and safety of tivozanib in 272 patients with advanced renal cell carcinoma were published in the Journal of Clinical Oncology. Results showed improved median progression-free survival or PFS among patients treated with tivozanib compared with placebo, and that tivozanib was well tolerated with minimal off-target toxicities, the company added.

Phase 2 trial's positive results informed the design and implementation of TIVO-1, a pivotal Phase 3 study in advanced RCC demonstrating tivozanib superiority over sorafenib in the primary endpoint of PFS in the first-line setting, top-line data from which were reported in January 2012.

Based on the positive Phase 2 data and success of the TIVO-1 trial, AVEO and its collaborator Astellas Pharma Inc. are moving forward with plans for submitting the tivozanib NDA in RCC in the third quarter of 2012, with the MAA submission to follow.

Click here to receive FREE breaking news email alerts for AVEO Pharmaceuticals, Inc. and others in your portfolio

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Ireland's economy grew for the second consecutive quarter in the three months to June, latest figures from the Central Statistics Office showed Thursday. Gross domestic product grew a seasonally adjusted 1.5 percent sequentially following 2.8 percent expansion in the first quarter, revised from 2.7... A historic referendum that decides the future of Scotland has begun. The Scots are voting Thursday on whether Scotland should become an independent country or stay in the United Kingdom. Voting opened at 7am local time in more than 2,600 polling stations, where voters are given the "Yes" and "No" options to the referendum question: "Should Scotland be an independent country?." More than four milli The European Central Bank announced Thursday the results of its first targeted longer term refinancing operation, or TLTRO, which is aimed to boost liquidity at Eurozone banks to help revive lending to small businesses and households. The central bank announced that 255 bidders were allotted EUR 82.60...
comments powered by Disqus
FREE Newsletters, Analysis & Alerts

 

Stay informed with our FREE daily Newsletters and real-time breaking News Alerts. Sign up to receive the latest information on business news, health, technology, biotech, market analysis, currency trading and more.