The following are some of the stocks making big moves in Wednesday's pre-market trading (as of 07.45 A.M. ET).
In the Green
INVO Bioscience, Inc. (INVO) is up over 73% at $1.35.Vanda Pharmaceuticals Inc. (VNDA) is up over 35% at $5.47.CXApp Inc. (CXAI) is up over 25% at $4.92.Chromocell Therapeutics Corporation (CHRO) is up over 23% at $2.24. Top Wealth Group Holding Limited (TWG) is up over 11% at $2.16.Enlivex Therapeutics Ltd. (ENLV) is up over 9% at $1.59.Rani Therapeutics Holdings, Inc. (RANI) is up over 8% at $7.45.TuanChe Limited (TC) is up over 7% at $2.09.Pacific Biosciences of California, Inc. (PACB) is up over 7% at $1.50.Siyata Mobile Inc. (SYTA) is up over 6% at $2.61.Rigetti Computing, Inc. (RGTI) is up over 6% at $1.29.ICZOOM Group Inc. (IZM) is up over 5% at $53.87.
In the Red
iLearningEngines, Inc (AILE) is down over 49% at $8.75.Destiny Tech100 Inc. (DXYZ) is down over 20% at $34.50.HUB Cyber Security Ltd. (HUBC) is down over 18% at $1.52.Connexa Sports Technologies Inc. (YYAI) is down over 17% at $1.74.China SXT Pharmaceuticals, Inc. (SXTC) is down over 14% at $1.38.Indonesia Energy Corporation Limited (INDO) is down over 8% at $4.31.Auddia Inc. (AUUD) is down over 8% at $2.06.J.B. Hunt Transport Services, Inc. (JBHT) is down over 7% at $170.02.Longeveron Inc. (LGVN) is down over 7% at $3.27.Better Choice Company Inc. (BTTR) is down over 6% at $5.89.Lipocine Inc. (LPCN) is down over 5% at $4.50.
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Business News
May 22, 2026 14:46 ET Minutes of the latest Fed policy session was the highlight of the week along with survey data on the U.S. housing market. In Europe, survey data signaled the trends in the euro area private sector. Further, consumer price inflation data from the U.K. was in focus. In Asia, various economic indicators from China drew attention to the health of the economy.