Genentech, a member of the Roche Group (RHHBY), announced that its Phase III INShore study evaluating Gazyva (obinutuzumab) in children and young adults aged 2 to 25 years with idiopathic nephrotic syndrome (INS) achieved statistically significant and clinically meaningful results.
The study met its primary endpoint, with more participants achieving sustained complete remission at one year (week 52) with Gazyva compared to mycophenolate mofetil (MMF). Sustained complete remission was defined as the absence of relapses and a urine protein-to-creatinine ratio of 0.2 or less at week 52. Several key secondary endpoints were also met.
No new safety signals were identified, and the safety profile remained consistent with Gazyva's established use in adults.
In addition to idiopathic nephrotic syndrome, Gazyva is being investigated in membranous nephropathy, lupus nephritis, rare immune-mediated kidney diseases and systemic lupus erythematosus.
Gazyva is also approved in 100 countries for various types of hematological cancers. In the U.S., Gazyva is part of a collaboration between Genentech and Biogen.
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June 05, 2026 16:18 ET A busy week for economic news flow saw a slew of reports being released that reflected the trends in the U.S. labor market. In Europe, economic growth and inflation data gained attention as the European Central Bank and Bank of England head for policy session later in the month. In Asia, the monetary policy session of the Indian central bank was in focus as the country, a major oil importer, reels under the pressures of a weaker rupee and rising inflation.