Monte Rosa Therapeutics, Inc. (GLUE), a clinical-stage biotechnology company, announced that the company has entered into a supply agreement with Johnson & Johnson(JNJ) to evaluate its MRT-2359 in combination with JNJ's ERLEADA or Apalutamide for the treatment of metastatic castration-resistant prostate cancer or mCRPC.
Following the news, GLUE is up 4.74% at $16.78.
As per the terms of the pact, Monte Rosa will conduct and sponsor the trial, and Johnson & Johnson will provide ERLEADA under a supply agreement.
MRT-2359 is Monte Rosa's investigational, orally bioavailable, GSPT1-directed molecular glue degrader.
ERLEADA is an androgen receptor inhibitor developed by Janssen Research and Development, LLC, indicated for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC) and patients with non-metastatic castration-resistant prostate cancer (nmCRPC).
Monte Rosa plans to initiate a new, signal-confirming Phase 2 study of MRT-2359 in combination with Apalutamide in AR-mutant patients in the third quarter of 2026.
The planned phase 2 study, enrolling up to 25 mCRPC patients, is designed to evaluate the efficacy and safety of MRT-2359 plus ERLEADA in patients with AR mutations.
The study will evaluate PSA response, RECIST response, duration of response, progression-free survival (PFS), radiographic progression-free survival (rPFS), and safety.
If the activity in the AR mutant patient population is confirmed, the study may expand to other additional patient subsets, including patients naïve to next-generation AR inhibitors.
Currently, MRT-2359, in combination with the AR inhibitor Enzalutamide, is being investigated by Monte Rosa in an ongoing Phase 1/2 study in patients with mCRPC.
According to the firm, in the ongoing Phase 1/2 clinical study for heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) patients with AR mutations, MRT-2359 showed compelling clinical activity in combination with androgen receptor (AR) inhibition.
For the third quarter ended September 30, 2025, Monte Rosa reported collaboration revenue of $12.8 million, compared to $9.2 million in the prior year.
Net loss for the third quarter of 2025 expanded to $27.1 million from $23.9 million in the prior year.
Cash, cash equivalents, and restricted cash were $396.2 million as of September 30, 2025.
GLUE has traded between $3.50 and $25.77 in the last year. The stock closed Friday's trade at $16.02.
For comments and feedback contact: editorial@rttnews.com
Business News
June 19, 2026 16:46 ET Major central banks continued to dominate the economic news flow this week too, led by the Federal Reserve, as they announced their latest policy decisions. The Federal Reserve policy session was in focus as it was the first to be led by the new chief Kevin Warsh. In Europe, central banks of the U.K. and Switzerland announced their rate decisions. In Asia, the Bank of Japan drew attention for its policy moves, while data out of China threw some light on the state of the economy.